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                           August 26, 2021

       Sumit Aggarwal
       Chief Executive Officer
       Eloxx Pharmaceuticals, Inc.
       480 Arsenal Way
       Watertown, MA 02472

                                                        Re: Eloxx
Pharmaceuticals, Inc.
                                                            Registration
Statement on Form S-3
                                                            Filed August 20,
2021
                                                            File No. 333-258994

       Dear Mr. Aggarwal:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Cara
Wirth at (202) 551-7127 with any questions.




                           Sincerely,


                           Division of Corporation Finance

                           Office of Trade & Services
       cc:                                              Peter N. Handrinos,
Esq.