United States

Securities and Exchange Commission

Washington, D.C. 20549

 

SCHEDULE 13D

(Amendment No. 2)*

 

ELOXX PHARMACEUTICALS, INC.

(Name of Issuer)

 

Common Stock Par Value $0.01 Per Share

(Title of Class of Securities)

 

29014R103

(CUSIP Number)

 

Asaf Shinar

Pontifax

14 Shenkar Street

Herzliya Pituach 46140, Israel

972-73-7073771

(Name, Address and Telephone Number of Person
Authorized to Receive Notices and Communications)

 

May 18, 2021

(Date of Event Which Requires Filing of this Statement)

 

If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box. ¨

 

Note: Schedules filed in paper format shall include a signed original and five copies of the schedule, including all exhibits. See § 240.13d-7 for other parties to whom copies are to be sent.

 

 

* The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

 

The information required on the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

 

 

 

 

 

 

1

Names of Reporting Persons

 

Pontifax Management III G.P. (2011) Ltd.
2 Check the Appropriate Box if a Member of a Group

(a) ¨
(b)
¨

 

3

SEC Use Only

  
4

Source of Funds (See Instructions)

 

OO – Ultimate general partner of the III Funds (see Item 2)

5

Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e) ¨

 

6

Citizenship or Place of Organization

 

Israel

NUMBER OF
SHARES
BENEFICIALLY
OWNED BY EACH
REPORTING
PERSON
WITH
7

Sole Voting Power

 

0

8

Shared Voting Power

 

7,188,1861

9

Sole Dispositive Power

 

0

10

Shared Dispositive Power

 

7,188,1861

11

Aggregate Amount Beneficially Owned by Each Reporting Person 1

 

7,188,1861

12

Check if the Aggregate Amount in Row (11) Excludes Certain Shares ¨  

 

13

Percent of Class Represented by Amount in Row (11)

 

8.34%2

14

Type of Reporting Person

 

CO

 

 

1 Includes (i) 2,287,937 shares of Common Stock held by Pontifax (Cayman) III, L.P. and (ii) 4,900,249 shares of Common Stock held by Pontifax (Israel) III, L.P.

2 All percentages calculated herein are based on 86,145,018 outstanding shares of Common Stock as of May 18, 2021.

 

 

 

 

1

Names of Reporting Persons

 

Pontifax Management Fund III L.P.
2 Check the Appropriate Box if a Member of a Group

(a) ¨
(b)
¨

 

3

SEC Use Only

  
4

Source of Funds (See Instructions)

 

OO – General partner of the III Funds (see Item 2)

5

Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e) ¨ 

 

6

Citizenship or Place of Organization

 

Israel

NUMBER OF
SHARES
BENEFICIALLY
OWNED BY EACH
REPORTING
PERSON
WITH
7

Sole Voting Power

 

0

8

Shared Voting Power

 

7,188,1861

9

Sole Dispositive Power

 

0

10

Shared Dispositive Power

 

7,188,1861

11

Aggregate Amount Beneficially Owned by Each Reporting Person 1

 

7,188,1861

12

Check if the Aggregate Amount in Row (11) Excludes Certain Shares ¨  

 

13

Percent of Class Represented by Amount in Row (11)

 

8.34%2

14

Type of Reporting Person

 

PN

 

 

1 Includes (i) 2,287,937 shares of Common Stock held by Pontifax (Cayman) III, L.P. and (ii) 4,900,249 shares of Common Stock held by Pontifax (Israel) III, L.P.

2 All percentages calculated herein are based on 86,145,018 outstanding shares of Common Stock as of May 18, 2021.

 

 

 

 

1

Names of Reporting Persons

 

Pontifax (Cayman) III, L.P.

2 Check the Appropriate Box if a Member of a Group

(a) ¨
(b)
¨

 

3

SEC Use Only

  
4

Source of Funds (See Instructions)

 

WC

5

Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e) ¨ 

 

6

Citizenship or Place of Organization

 

Cayman Islands

NUMBER OF
SHARES
BENEFICIALLY
OWNED BY EACH
REPORTING
PERSON
WITH
7

Sole Voting Power

 

0

8

Shared Voting Power

 

2,287,937

9

Sole Dispositive Power

 

0

10

Shared Dispositive Power

 

2,287,937

11

Aggregate Amount Beneficially Owned by Each Reporting Person

 

2,287,937

12

Check if the Aggregate Amount in Row (11) Excludes Certain Shares ¨  

 

13

Percent of Class Represented by Amount in Row (11)

 

2.66%1

14

Type of Reporting Person

 

PN

 

 

1 All percentages calculated herein are based on 86,145,018 outstanding shares of Common Stock as of May 18, 2021.

 

 

 

 

1

Names of Reporting Persons

 

Pontifax (Israel) III, L.P.

2 Check the Appropriate Box if a Member of a Group

(a) ¨
(b)
¨

 

3

SEC Use Only

  
4

Source of Funds (See Instructions)

 

WC

5

Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e) ¨ 

 

6

Citizenship or Place of Organization

 

Israel

NUMBER OF
SHARES
BENEFICIALLY
OWNED BY EACH
REPORTING
PERSON
WITH
7

Sole Voting Power

 

0

8

Shared Voting Power

 

4,900,249

9

Sole Dispositive Power

 

0

10

Shared Dispositive Power

 

4,900,249

11

Aggregate Amount Beneficially Owned by Each Reporting Person

 

4,900,249

12

Check if the Aggregate Amount in Row (11) Excludes Certain Shares ¨  

 

13

Percent of Class Represented by Amount in Row (11)

 

5.69%1

14

Type of Reporting Person

 

PN

 

 

1 All percentages calculated herein are based on 86,145,018 outstanding shares of Common Stock as of May 18, 2021.

 

 

 

 

1

Names of Reporting Persons

 

Pontifax Management 4 G.P. (2015) Ltd.

2 Check the Appropriate Box if a Member of a Group

(a) ¨
(b)
¨

 

3

SEC Use Only

  
4

Source of Funds (See Instructions)

 

OO – Ultimate general partner of the IV Funds (see Item 2)

5

Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e) ¨ 

 

6

Citizenship or Place of Organization

 

Israel

NUMBER OF
SHARES
BENEFICIALLY
OWNED BY EACH
REPORTING
PERSON
WITH
7

Sole Voting Power

 

0

8

Shared Voting Power

 

7,460,8181

9

Sole Dispositive Power

 

0

10

Shared Dispositive Power

 

7,460,8181

11

Aggregate Amount Beneficially Owned by Each Reporting Person 1

 

7,460,8181

12

Check if the Aggregate Amount in Row (11) Excludes Certain Shares ¨  

 

13

Percent of Class Represented by Amount in Row (11)

 

8.66%2

14

Type of Reporting Person

 

CO

 

 

1 Includes (i) 1,791,470 shares of Common Stock held by Pontifax (Cayman) IV L.P., (ii) 3,679,797 shares of Common Stock held by Pontifax (Israel) IV, L.P., and (iii) 1,989,551 shares of Common Stock held by Pontifax (China) IV L.P.

2 All percentages calculated herein are based on 86,145,018 outstanding shares of Common Stock as of May 18, 2021.

 

 

 

 

1

Names of Reporting Persons

 

Pontifax IV GP L.P.

2 Check the Appropriate Box if a Member of a Group

(a) ¨
(b)
¨

 

3

SEC Use Only

  
4

Source of Funds (See Instructions)

 

OO – General partner of the IV Funds (see Item 2)

5

Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e) ¨ 

 

6

Citizenship or Place of Organization

 

Israel

NUMBER OF
SHARES
BENEFICIALLY
OWNED BY EACH
REPORTING
PERSON
WITH
7

Sole Voting Power

 

0

8

Shared Voting Power

 

7,460,8181

9

Sole Dispositive Power

 

0

10

Shared Dispositive Power

 

7,460,8181

11

Aggregate Amount Beneficially Owned by Each Reporting Person 1

 

7,460,8181

12

Check if the Aggregate Amount in Row (11) Excludes Certain Shares ¨  

 

13

Percent of Class Represented by Amount in Row (11)

 

8.66%2

14

Type of Reporting Person

 

PN

 

 

1 Includes (i) 1,791,470 shares of Common Stock held by Pontifax (Cayman) IV L.P., (ii) 3,679,797 shares of Common Stock held by Pontifax (Israel) IV, L.P., and (iii) 1,989,551 shares of Common Stock held by Pontifax (China) IV L.P.

2 All percentages calculated herein are based on 86,145,018 outstanding shares of Common Stock as of May 18, 2021.

 

 

 

 

1

Names of Reporting Persons

 

Pontifax (Cayman) IV L.P.

2 Check the Appropriate Box if a Member of a Group

(a) ¨
(b)
¨

 

3

SEC Use Only

  
4

Source of Funds (See Instructions)

 

WC

5

Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e) ¨ 

 

6

Citizenship or Place of Organization

 

Cayman Islands

NUMBER OF
SHARES
BENEFICIALLY
OWNED BY EACH
REPORTING
PERSON
WITH
7

Sole Voting Power

 

0

8

Shared Voting Power

 

1,791,470

9

Sole Dispositive Power

 

0

10

Shared Dispositive Power

 

1,791,470

11

Aggregate Amount Beneficially Owned by Each Reporting Person

 

1,791,470

12.

Check if the Aggregate Amount in Row (11) Excludes Certain Shares ¨  

 

13

Percent of Class Represented by Amount in Row (11)

 

2.08%1

14

Type of Reporting Person

 

PN

 

 

1 All percentages calculated herein are based on 86,145,018 outstanding shares of Common Stock as of May 18, 2021.

 

 

 

 

1

Names of Reporting Persons

 

Pontifax (Israel) IV L.P.

2 Check the Appropriate Box if a Member of a Group

(a) ¨
(b)
¨

 

3

SEC Use Only

  
4

Source of Funds (See Instructions)

 

WC

5

Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e) ¨ 

 

6

Citizenship or Place of Organization

 

Israel

NUMBER OF
SHARES
BENEFICIALLY
OWNED BY EACH
REPORTING
PERSON
WITH
7

Sole Voting Power

 

0

8

Shared Voting Power

 

3,679,797

9

Sole Dispositive Power

 

0

10

Shared Dispositive Power

 

3,679,797

11

Aggregate Amount Beneficially Owned by Each Reporting Person

 

3,679,797

12

Check if the Aggregate Amount in Row (11) Excludes Certain Shares ¨  

 

13

Percent of Class Represented by Amount in Row (11)

 

4.27%1

14

Type of Reporting Person

 

PN

 

 

1 All percentages calculated herein are based on 86,145,018 outstanding shares of Common Stock as of May 18, 2021.

 

 

 

 

1

Names of Reporting Persons

 

Pontifax (China) IV L.P.

2 Check the Appropriate Box if a Member of a Group

(a) ¨
(b)
¨

 

3

SEC Use Only

  
4

Source of Funds (See Instructions)

 

WC

5

Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e) ¨ 

 

6

Citizenship or Place of Organization

 

Cayman Islands

NUMBER OF
SHARES
BENEFICIALLY
OWNED BY EACH
REPORTING
PERSON
WITH
7

Sole Voting Power

 

0

8

Shared Voting Power

 

1,989,551

9

Sole Dispositive Power

 

0

10

Shared Dispositive Power

 

1,989,551

11

Aggregate Amount Beneficially Owned by Each Reporting Person

 

1,989,551

12

Check if the Aggregate Amount in Row (11) Excludes Certain Shares ¨  

 

13

Percent of Class Represented by Amount in Row (11)

 

2.31%1

14

Type of Reporting Person

 

PN

 

 

1 All percentages calculated herein are based on 86,145,018 outstanding shares of Common Stock as of May 18, 2021.

 

 

 

 

1

Names of Reporting Persons

 

Pontifax Late Stage GP Ltd.

2 Check the Appropriate Box if a Member of a Group

(a) ¨
(b)
¨

 

3

SEC Use Only

  
4

Source of Funds (See Instructions)

 

OO – General partner of LS (See Item 2)

5

Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e) ¨ 

 

6

Citizenship or Place of Organization

 

Israel

NUMBER OF
SHARES
BENEFICIALLY
OWNED BY EACH
REPORTING
PERSON
WITH
7

Sole Voting Power

 

0

8

Shared Voting Power

 

616,5921

9

Sole Dispositive Power

 

0

10

Shared Dispositive Power

 

616,5921

11

Aggregate Amount Beneficially Owned by Each Reporting Person

 

616,5921

12

Check if the Aggregate Amount in Row (11) Excludes Certain Shares ¨  

 

13

Percent of Class Represented by Amount in Row (11)

 

0.72%2

14

Type of Reporting Person

 

CO

 

 

1 Includes 616,592 shares of Common Stock held by Pontifax Late-Stage Fund L.P.

2 All percentages calculated herein are based on 86,145,018 outstanding shares of Common Stock as of May 18, 2021.

 

 

 

 

1

Names of Reporting Persons

 

Pontifax Late Stage Fund L.P.

2 Check the Appropriate Box if a Member of a Group

(a) ¨
(b)
¨

 

3

SEC Use Only

  
4

Source of Funds (See Instructions)

 

WC

5

Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e) ¨ 

 

6

Citizenship or Place of Organization

 

Cayman Islands

NUMBER OF
SHARES
BENEFICIALLY
OWNED BY EACH
REPORTING
PERSON
WITH
7

Sole Voting Power

 

0

8

Shared Voting Power

 

616,592

9

Sole Dispositive Power

 

0

10

Shared Dispositive Power

 

616,592

11

Aggregate Amount Beneficially Owned by Each Reporting Person

 

616,592

12

Check if the Aggregate Amount in Row (11) Excludes Certain Shares ¨  

 

13

Percent of Class Represented by Amount in Row (11)

 

0.72%1

14

Type of Reporting Person

 

PN

 

 

1 All percentages calculated herein are based on 86,145,018 outstanding shares of Common Stock as of May 18, 2021.

 

 

 

 

Item 2.

 

Item 2 is amended and supplemented as follows:

 

This statement is being filed on behalf of (1) Pontifax Management III G.P. (2011) Ltd. (“Management III”), (2) Pontifax Management Fund III L.P. (“Pontifax III”), (3) Pontifax (Cayman) III, L.P. (“Cayman III”), (4) Pontifax (Israel) III, L.P., (“Israel III”) (together with Cayman III, the “III Funds”), (5) Pontifax Management 4 G.P. (2015) Ltd. (“Management 4”), (6) Pontifax IV GP L.P. (“Pontifax IV”), (7) Pontifax (Cayman) IV L.P. (“Cayman IV”), (8) Pontifax (Israel) IV, L.P. (“Israel IV”), (9) Pontifax (China) IV L.P. (“China IV”) (together with Cayman IV and Israel IV, the “IV Funds”) and (10) Pontifax Late Stage Fund L.P. (“Late Stage Fund”) and (7) Pontifax Late Stage GP Ltd. (“Late Stage GP”) (together with Management III, Pontifax III, the III Funds, Management 4 and Pontifax IV, the IV Funds, and Late Stage Fund, the “Reporting Persons”).

 

Each of Management III, Pontifax III, Israel III, Management 4, Pontifax IV and Late Stage GP, are organized under the laws of Israel. Each of Cayman III, Cayman IV, China IV and Late Stage Fund are organized under the laws of the Cayman Islands. The business address of each of the Reporting Persons is c/o Pontifax, 14 Shenkar Street, Beit Ofek, Herzliya Pituach, 46140 Israel.

 

The Reporting Persons are principally engaged in the business of long-term, venture-type investments in high growth pharmaceutical, biotechnological and medical device companies.

 

The managing partners of Management III and Management 4 are Tomer Kariv and Ran Nussbaum (together, the “Related Persons”). Messrs. Kariv and Nussbaum are citizens of Israel. The business address of each of the Related Persons is c/o Pontifax, 14 Shenkar Street, Beit Ofek, Herzliya Pituach, 46140 Israel. The current principal occupation of each of the Related Persons is Managing Partner of Pontifax.

 

Late Stage Fund invests side by side with the IV Funds. Late Stage GP is the ultimate general partner of Late Stage L.P., the sole shareholder of Late Stage GP is Mr. Shlomo Karako. The business address of Mr. Shlomo Karako. is c/o Pontifax, 14 Shenkar Street, Beit Ofek, Herzliya Pituach.

 

During the last five years, none of the Reporting Persons or Related Persons (i) has been convicted in any criminal proceeding (excluding traffic violations and similar misdemeanors) or (ii) was a party to a civil proceeding of a judicial or administrative body of competent jurisdiction which as a result of such proceeding was or is subject to a judgment, decree or final order enjoining future violations of, or prohibiting or mandating activities subject to, federal or state securities laws or finding any violation with respect to such laws.

 

Item 3. Source and Amount of Funds or Other Consideration.

 

Item 3 is amended and supplemented as follows:

 

The Reporting Persons purchased the shares of Common Stock described in Item 5(c) using funds from working capital.

 

Item 5. Interest in Securities of the Issuer.

 

Item 5 is amended and restated as follows:

 

(a) – (b)

 

The following sets forth the aggregate number and percentage of shares of Common Stock beneficially owned by each of the Reporting Persons, as well as the number of shares of Common Stock as to which each Reporting Person has the sole power to vote or to direct the vote, shared power to vote or to direct the vote, sole power to dispose or to direct the disposition, or shared power to dispose or to direct the disposition of as of the date hereof.

 

 

 

 

The ownership percentages reported are based on 86,145,018 outstanding shares of Common Stock, as of May 18, 2021 after giving effect to the Issuer’s underwritten public offering (the “Offering”), as disclosed in the Issuer’s prospectus supplement for the Offering filed with the SEC on May 18, 2021.

 

Reporting Person   Amount
beneficially
owned
    Percent
of class
    Sole power to
vote or direct
the vote
    Shared
power to vote
or direct the
vote
    Sole power to
dispose or to
direct the
disposition of
    Shared power
to dispose or to
direct the
disposition of
 
Pontifax Management III G.P. (2011) Ltd.     7,188,186 1     8.34 %1     0       7,188,186       0       7,188,186  
Pontifax Management Fund III L.P.     7,188,186 1     8.34 %1     0       7,188,186       0       7,188,186  
Pontifax (Cayman) III, L.P.     2,287,937       2.66 %     0       2,287,937       0       2,287,937  
Pontifax (Israel) III, L.P.     4,900,249       5.69 %     0       4,900,249       0       4,900,249  
Pontifax Management 4 G.P. (2015) Ltd.     7,460,818 2     8.66 %2     0       7,460,818       0       7,460,818  
Pontifax IV GP L.P.     7,460,818 2     8.66 %2     0       7,460,818       0       7,460,818  
Pontifax (Cayman) IV L.P.     1,791,470       2.08 %     0       1,791,470       0       1,791,470  
Pontifax (Israel) IV, L.P.     3,679,791       4.27 %     0       3,679,791       0       3,679,791  
Pontifax (China) IV L.P.     1,989,551       2.31 %     0       1,989,551       0       1,989,551  
Pontifax Late Stage GP Ltd.     616,592       0.72% 3     0       616,592       0       616,592  
Pontifax Late Stage Fund L.P.     616,592       0.72%     0       616,592       0       616,592  

 

1 Includes (i) 2,287,937 shares of Common Stock held by Pontifax (Cayman) III, L.P. and (ii) 4,900,249 shares of Common Stock held by Pontifax (Israel) III, L.P. Management III and Pontifax III each disclaims beneficial ownership of any shares owned beneficially or of record by any other person named in this Item 5(a)-(b), except to the extent of its pecuniary interest therein.

 

2 Includes (i) 1,791,470 shares of Common Stock held by Pontifax (Cayman) IV L.P., (ii) 3,679,791 shares of Common Stock held by Pontifax (Israel) IV, L.P., and (iii) 1,989,551 shares of Common Stock held by Pontifax (China) IV L.P. Management 4 and Pontifax IV each disclaims beneficial ownership of any shares owned beneficially or of record by any other person named in this Item 5(a)-(b), except to the extent of its pecuniary interest therein.

 

3 Includes 616,592 shares of Common Stock held by Pontifax Late-Stage Fund L.P. Late Stage GP disclaims beneficial ownership of any shares owned beneficially or of record by any other person named in this Item 5(a)-(b), except to the extent of its pecuniary interest therein.

 

Cayman III is the holder of record of 2,287,937 shares of Common Stock. Israel III is the holder of 4,900,249 shares of Common Stock. Cayman IV is the holder of record of 1,791,470 shares of Common Stock. Israel IV is the record holder of 3,679,797 shares of Common Stock. China IV is the holder of record of 1,989,551 shares of Common Stock. Management III is the ultimate general partner of Cayman III and Israel III and Management 4 is the ultimate general partner of Cayman IV, Israel IV and China IV. Messrs. Ran Nussbaum and Tomer Kariv are the managing partners of each of Management III and Management 4. As such, each of Pontifax III, Management III, Ran Nussbaum, and Tomer Kariv may be deemed to beneficially own shares of Common Stock of the III Funds and each of Pontifax IV, Management 4, Ran Nussbaum, and Tomer Kariv may be deemed to beneficially own shares of Common Stock of the IV Funds.

 

 

 

 

Late Stage Fund is the holder of record of 616,592 shares of Common Stock. Late Stage GP is the ultimate general partner of Late Stage Fund. Pursuant to that Certain Strategic Alliance Agreement dated August 9, 2018, between the IV Funds and Late Stage GP, Late Stage Fund invests side-by-side with the IV Funds. By virtue of the strategic relationship, each of Pontifax IV, Management IV, Ran Nussbaum, and Tomer Kariv may be deemed to share voting and dispositive power with respect to the shares held by Late Stage Fund.

 

Except as set forth in this Item 5(a)-(b), each of the persons named in this Item 5(a)-(b) disclaims beneficial ownership of any shares of Common Stock owned beneficially or of record by any other person named in this Item 5(a)-(b).

 

(c) On May 18, 2021, the Reporting Persons, together with the Late Stage Fund, purchased at the closing of the Offering an aggregate of 5,925,925 shares of Common Stock at a price of $1.35 per share.

 

(d)-(e) Not applicable

 

Item 6.Contracts, Arrangements, Understandings or Relationships With Respect to Securities of the Issuer.

 

Item 6 is amended and supplemented as follows:

 

In connection with the Offering, the Reporting Persons agreed, for a period of 90 days from the date of the prospectus for the Offering, not to, without the prior written consent of B. Riley Securities, Inc., offer, sell, contract to sell, pledge or otherwise dispose of, including the filing of a registration statement in respect of, or hedge any shares of the Common Stock or any securities convertible into, or exercisable or exchangeable for, the Common Stock, subject to certain limited exceptions.

 

Item 7. Material to Be Filed as Exhibits.

 

EXHIBIT INDEX

 

Exhibit   Description
     
1.   Joint Filing Agreement as required by Rule 13d-1(k)(1) under the Securities and Exchange Act of 1934, as amended (incorporated by reference to Exhibit 1 to Schedule 13D filed by the Reporting Persons with respect to the Issuer with the SEC on December 29, 2017.  
2.     Form of Lock-Up Agreement dated May 10, 2021, between Eloxx Pharmaceuticals, Inc. and the Reporting Persons (incorporated by reference to Exhibit 1.1 to the Issuer’s Form 8-K filed on May 18, 2021.  
3   Strategic Alliance Agreement dated August 9, 2018.  

 

 

 

 

SIGNATURE

After reasonable inquiry and to the best of its knowledge and belief, the undersigned certifies that the information set forth in this statement is true, complete and correct.

 

  Dated: May 21, 2021
   
  Pontifax Management III G.P. (2011) Ltd.
   
  By: /s/ Neil S. Belloff
  Name:  Neil S. Belloff
  Title: Attorney in Fact

 

  PONTIFAX MANAGEMENT FUND III L.P.
     
  By: /s/ Neil S. Belloff
  Name:  Neil S. Belloff
  Title: Attorney in Fact
     
  PONTIFAX (CAYMAN) III, L.P.
     
  By: /s/ Neil S. Belloff
  Name: Neil S. Belloff
  Title: Attorney in Fact
     
  PONTIFAX (ISRAEL) III, L.P.
     
  By: /s/ Neil S. Belloff
  Name: Neil S. Belloff
  Title: Attorney in Fact
     
  Pontifax Management 4 G.P. (2015) Ltd.
     
  By: /s/ Neil S. Belloff
  Name: Neil S. Belloff
  Title: Attorney in Fact
     
  PONTIFAX IV GP L.P.
     
  By: /s/ Neil S. Belloff
  Name: Neil S. Belloff
  Title: Attorney in Fact
     
  PONTIFAX (CAYMAN) IV L.P.
     
  By: /s/ Neil S. Belloff
  Name: Neil S. Belloff
  Title: Attorney in Fact

 

 

 

 

  PONTIFAX (ISRAEL) IV, L.P.
     
  By: /s/ Neil S. Belloff
  Name:  Neil S. Belloff
  Title: Attorney in Fact
   
  PONTIFAX (CHINA) IV L.P.
     
  By: /s/ Neil S. Belloff
  Name: Neil S. Belloff
  Title: Attorney in Fact
     
  PONTIFAX LATE STAGE FUND L.P.
  By: /s/ Neil S. Belloff
  Name: Neil S. Belloff
  Title: Attorney in Fact
     
  PONTIFAX LATE STAGE GP LTD.
  By: /s/ Neil S. Belloff
  Name: Neil S. Belloff
  Title: Attorney in Fact

 

 

 

 

Exhibit 3

 

STRATEGIC ALLIANCE AGREEMENT

 

This Strategic Alliance Agreement (the "Agreement ") is made as of August 9, 2018 (the "Effective Date"), by and between Pontifax IV GP LP ("GP4"), Pontifax V GP LP ("GP5") and Pontifax Late Stage GP Ltd ("LS GP").

 

1.All capitalized terms used and not defined herein shall have the meaning ascribed thereto in the Limited Partnership Agreement dated August 9, 2018, by and among Pontifax LS, Pontifax GP II Limited and [AIG LP] (the "Partnership Agreement").

 

2.GP5 is the general partner of Pontifax (Israel) 5 LP, Pontifax (Cayman) 5 LP, and Pontifax (China) 5 LP ("Pontifax 5"). GP5 hereby undertakes to use best efforts to enable Pontifax Late Stage Fund LP ("Pontifax LS") to participate in any round of investment in which Pontifax 5 intends to invest at least US$ 10,000,000 side by side to the extent participation is feasible.

 

3.GP4 is the general partner of Pontifax (Israel) 4 LP, Pontifax (Cayman) 4 LP, and Pontifax (China) 4 LP ("Pontifax 4"). GP4 undertakes to use best efforts to enable Pontifax LS to participate in any follow-on investments of Pontifax 4 in its portfolio companies in which Pontifax 4 intends to invest at least US$ 15,000,000 side by side to the extent participation is feasible.

 

4.Investment with either Pontifax 4 or Pontifax 5, in accordance with Section 2 or 3 above, as applicable, will be made on a pro-rata basis based on committed but un-invested amount of each party and the amount invested by Pontifax LS shall not be higher than 20% of the aggregate amount invested by Pontifax 4 or Pontifax 5, as applicable, in such portfolio company.

 

5.Each of GP4 or GP5, as applicable, will use its best efforts to notify LS GP regarding its intention to dispose or sell securities of a portfolio company of Pontifax 4 or Pontifax 5, as applicable.

 

6.In the event that either Mr. Tomer Kariv or Mr. Ran Nussbaum shall no longer devote substantially all of his business time and attention to managing the affairs and activities of Pontifax 4 or Pontifax 5, then GP4 or GP5, as applicable, shall provide LS GP with prompt notice.

 

7.This Agreement shall be exclusively governed by and construed in accordance with the laws of the Cayman Islands. The competent court of London, England shall have exclusive jurisdiction in all matters relating to or arising from this Agreement.

 

8.This Agreement may be executed in one or more counterparts, each of which shall be an original, but all of which when taken together shall constitute one instrument.

 

[SIGNATURE PAGE FOLLOWS]

 

 

 

 

IN WITNESS WHEREOF, the parties have executed this agreement as of the Effective Date.

 

/s/ Ran Nussbaum  
Pontifax 4 GP LP  
   
By: Ran Nussbaum  
   
/s/ Ran Nussbaum  
Pontifax 5 GP LP  
   
By: Ran Nussbaum